Male Infertility - Pregnancy - How to improve sperm count

Posted by Wesley Inman on 2nd Apr 2022

https://stores.gymntonic.com/humanofort-whole-body-recovery/

Reviewed medical treatment of male infertility

Substance	Administration	Dosage and frequency	Current availability
GnRH	Subcutaneous infusion pump	25-200 ng/kg per pulse every 2 hours	Only in specialty centers or part of clinical trials
Human chorionic-gonadotropin (hCG)	Subcutaneous/intramuscular	1,500-3,000 IU 2 times/week	Available, FDA approved for treatment of infertility due to gonadotropin deficiency
Human menopausal gonadotropin (hMG)	Subcutaneous/intramuscular	75 IU 2-3 times/week	Available, FDA approved for treatment of infertility due to gonadotropin deficiency
Highly purified or recombinant human follicle-stimulating hormone (rhFSH)	Subcutaneous/intramuscular	100-150 IU 2-3 times/week	Available, FDA approved for treatment of infertility due to gonadotropin deficiency
Dopamine agonist	Oral	Cabergoline (0.5-1 mg twice weekly), bromocriptine (2.5-5.0 mg twice weekly)	FDA approval for treatment of hyperprolactinaemia
Aromatase inhibitors	Oral	Anastrozole 1 mg/day	Off label use
Letrozole 2.5 mg/day	Off label use
Testolactone	Not available in the USA
Selective estrogen receptor modulators (SERMs)	Oral	Clomiphene citrate titrate to 50 mg/day	Off label use
Tamoxifen 20 mg/day, toremifene 60 mg/day, raloxifene 60 mg/day	Off label use

How long does it take for HMG and HCG to be effective in improving sperm count?

On the average according to multiple studies, it takes about 3 months of consistent administration to see decent results.
15-25million Sperm is the average rate of improvement in men in these studies
https://onlinelibrary.wiley.com/doi/10.1111/and.13271

How much does it cost to use one of these protocols?

Depending on what you choose, it is very pricy overall. If you can get things like Clomid, HCG and HMG prescribed to you and your insurance covers it, great. If you have to pay out of pocket it will get very pricy very quick

HMG alone averages on the black market about $50 for 75iu, and the standard dose of HMG is 75-150 per week. So you can see that this alone is going to cost you $2-400 alone per month.

Does a protocol always work?

Of course not. Plenty of variable exist and even if you do improve your sperm count, their may be other reasons that it won't work, and also it must be evaluated whether your wife/gf/partner is able to conceive etc.

Why does infertility happen?

About 15% of couples are infertile and male factor infertility contributes to about 50% of the infertility cases (1). The majority of male infertility is idiopathic, which indicates that the patient has unexplained abnormalities in sperm parameters, or unexplained azoospermia. However, there are multiple known causes of male infertility, and several have a pharmacologic option as the first line of treatment. The medical treatment of known causes of male infertility tend to have targeted and high success rates. In cases of idiopathic or genetic causes of male infertility, the medical management tends to be empirical and is directed for the purposes of optimization.
It is important to appreciate that testicular function involves both the production of testosterone (T) and spermatogenesis, and this function is highly regulated by the hypothalamic-pituitary-gonadal (HPG) axis. Spermatogenesis is dependent on high levels of intratesticular T and follicle-stimulating hormone (FSH) stimulation of the Sertoli cells (2). Despite the requirement for T for spermatogenesis, the administration of T and other androgens have contraceptive properties; they exhibit a negative feedback on HPG and thus inhibit luteinizing hormone (LH) stimulation of intratesticular T production, as well as FSH stimulation of Sertoli cells, and should be avoided. For most known causes of male infertility, the therapeutic goal is the maintenance of the reproductive axis to increase testicular T. However, in certain men with primary testicular failure or idiopathic male infertility, a specific medical therapy has not been identified, and empiric medical treatments are often used. This review article will focus on the non-surgical treatments currently available for male infertility and review the data on the efficacy of those therapies, the list of medications reviewed are summarized in Table 1.

[h=2]Conclusions[/h]Understanding the HPG axis and the effect of estrogen excess is critical for the assessment and treatment of male infertility. However, the goal of infertility treatment in all these men is to optimize LH levels to stimulate T production from the Leydig cells, FSH levels to stimulate Sertoli cells and spermatogenesis, and eliminate any estrogen excess. Pharmacologic therapy is only effective in a handful of known causes of male infertility where the causes are relatively well-defined and understood. Based on current data, hormonal therapies in general should not be used indiscriminately for the treatment of idiopathic male infertility due to questionable efficacy and restrictive cost.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708300/www.gymntonic.mymusclepay.com

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